With the evolving threat of climate change and the consequences of industrial accidents to becoming more severe, there is an increasing need for First Responders to access reliable and agile information management systems that offer as higher Situational Awareness and better Common Operational Picture. To match with current trends, the RESPOND-A project aims at developing holistic and easy-to-use solutions for First Responders harnessing the power of the latest technological innovations including 5G, Augmented Reality, Virtual Reality, Autonomous Robots, Unmanned Aerial Vehicles, smart equipment and more.